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Sequence heterogeneity and the dynamics of molecular motors | | Yariv Kafri
; David R. Nelson
; | | Date: |
30 Jun 2005 | | Subject: | Statistical Mechanics; Soft Condensed Matter; Biomolecules | cond-mat.stat-mech cond-mat.soft q-bio.BM | | Abstract: | The effect of sequence heterogeneity on the dynamics of molecular motors is reviewed and analyzed using a set of recently introduced lattice models. First, we review results for the influence of heterogenous tracks such as a single-strand of DNA or RNA on the dynamics of the motors. We stress how the predicted behavior might be observed experimentally in anomalous drift and diffusion of motors over a wide range of parameters near the stall force and discuss the extreme limit of strongly biased motors with one-way hopping. We then consider the dynamics in an environment containing a variety of different fuels which supply chemical energy for the motor motion, either on a heterogeneous or on a periodic track. The results for motion along a periodic track are relevant to kinesin motors in a solution with a mixture of different nucleotide triphosphate fuel sources. | | Source: | arXiv, cond-mat/0506797 | | Services: | Forum | Review | PDF | Favorites | |
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