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Are scale-free regulatory networks larger than random ones? | Miguel A. Fortuna
; Carlos J. Melian
; | Date: |
19 Dec 2004 | Subject: | Genomics; Molecular Networks | q-bio.GN q-bio.MN | Abstract: | Network of packages with regulatory interactions (dependences and conflicts) from Debian GNU/Linux operating system is compiled and used as analogy of a gene regulatory network. Using a trace-back algorithm we assembly networks from the potential pool of packages for both scale-free and exponential topology from real and a null model data, respectively. We calculate the maximum number of packages that can be functionally installed in the system (i.e., the active network size). We show that scale-free regulatory networks allow a larger active network size than random ones. Small genomes with scale-free regulatory topology could allow much more functionality than large genomes with an exponential one, with implications on its dynamics, robustness and evolution. | Source: | arXiv, q-bio.GN/0501027 | Services: | Forum | Review | PDF | Favorites |
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