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29 March 2024
 
  » arxiv » q-bio.TO/0502036

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Morphogen Gradient from a Noisy Source
Jeremy L. England ; John Cardy ;
Date 24 Feb 2005
Journal PRL 94, 078101 (2005) DOI: 10.1103/PhysRevLett.94.078101
Subject Tissues and Organs; Molecular Networks; Other | q-bio.TO cond-mat.other q-bio.MN q-bio.OT
AbstractWe investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed.
Source arXiv, q-bio.TO/0502036
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