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Some protein interaction data do not exhibit power law statistics | | Reiko Tanaka
; Tau-Mu Yi
; John Doyle
; | | Date: |
27 Jun 2005 | | Journal: | FEBS Letters 579 (2005) 514--5144 DOI: 10.1016/j.febslet.2005.08.024 | | Subject: | Molecular Networks | q-bio.MN | | Abstract: | It has been claimed that protein-protein interaction (PPI) networks are scale-free based on the observation that the node degree sequence follows a power law. Here we argue that these claims are likely to be based on erroneous statistical analysis. Typically, the supporting data are presented using frequency-degree plots. We show that such plots can be misleading, and should correctly be replaced by rank-degree plots. We provide two PPI network examples in which the frequency-degree plots appear linear on a log-log scale, but the rank-degree plots demonstrate that the node degree sequence is far from a power law. We conclude that at least these PPI networks are not scale-free. | | Source: | arXiv, q-bio.MN/0506038 | | Services: | Forum | Review | PDF | Favorites | |
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