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Bayesian Method for Disease QTL Detection and Mapping, using a Case and Control Design and DNA Pooling | | Toby Johnson
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13 Jul 2005 | | Subject: | Genomics; Populations and Evolution; Quantitative Methods | q-bio.GN q-bio.PE q-bio.QM | | Abstract: | This paper describes a Bayesian statistical method for determining the genetic basis of a complex genetic trait. The method uses a sample of unrelated individuals classified into two groups, for example cases and controls. Each group is assumed to have been genotyped at a battery of marker loci using a laboratory effort efficient technique called DNA pooling. The aim is to detect and map a quantitative trait locus (QTL) that is not one of the typed markers. The method works by conducting an exact Bayesian analysis under a number of simplifying population genetic assumptions that are somewhat unrealistic. Despite this, the method is shown to perform acceptably on datasets simulated under a more realistic model, and furthermore is shown to outperform classical single point methods. | | Source: | arXiv, q-bio.GN/0507018 | | Services: | Forum | Review | PDF | Favorites | |
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