|
| | | | |
| | | |
| Stat |
Members: 3645
Articles: 2'504'585
Articles rated: 2609
25 April 2024 |
|
| | | | |
|
Article overview
| |
|
|
A simple physical model for scaling in protein-protein interaction networks | | Eric J. Deeds
; Orr Ashenberg
; Eugene I. Shakhnovich
; | | Date: |
1 Sep 2005 | | Subject: | Molecular Networks; Biomolecules | q-bio.MN q-bio.BM | | Abstract: | It has recently been demonstrated that many biological networks exhibit a scale-free topology where the probability of observing a node with a certain number of edges (k) follows a power law: i.e. p(k) ~ k^-g. This observation has been reproduced by evolutionary models. Here we consider the network of protein-protein interactions and demonstrate that two published independent measurements of these interactions produce graphs that are only weakly correlated with one another despite their strikingly similar topology. We then propose a physical model based on the fundamental principle that (de)solvation is a major physical factor in protein-protein interactions. This model reproduces not only the scale-free nature of such graphs but also a number of higher-order correlations in these networks. A key support of the model is provided by the discovery of a significant correlation between number of interactions made by a protein and the fraction of hydrophobic residues on its surface. The model presented in this paper represents the first physical model for experimentally determined protein-protein interactions that comprehensively reproduces the topological features of interaction networks. These results have profound implications for understanding not only protein-protein interactions but also other types of scale-free networks. | | Source: | arXiv, q-bio.MN/0509001 | | Services: | Forum | Review | PDF | Favorites | |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
|
| |
|
|
|
|
News, job offers and information for researchers and scientists:
| |
REGISTER