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Article overview
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Universal core modules govern the dynamics of cellular regulatory networks | | Jing-Jing Li
; Jie Ren
; Zhi Liang
; Meng Xu
; Dan Xie
; De-Shuang Huang
; Bing-Hong Wang
; Liwen Niu
; Huanqing Feng
; Wen-Xu Wang
; | | Date: |
10 Jan 2006 | | Subject: | Molecular Networks; Genomics | | Abstract: | The transcription factors, target genes and their regulatory interaction constitute a transcriptional regulatory network, which dominate the biological functions within a cell. With a simple dynamical model, we have studied how the regulatory networks behave in diverse cellular conditions. Our experimental results reveal the existence of the universal core modules that exclusively determine dynamical behaviors for different conditions. Moreover, it is found that dynamical properties are more useful for classifying the cellular conditions than pure topological information. We also exhibit that genetic networks of cells in the normal condition is poised near the edge of the chaos while ones in abnormal conditions operate in a more stable regime. | | Source: | arXiv, q-bio/0601012 | | Services: | Forum | Review | PDF | Favorites | |
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