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28 March 2024
 
  » arxiv » q-bio/0608002

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Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity
Leor S. Weinberger ; John C. Burnett ; Jared E. Toettcher ; Adam P. Arkin ; David V. Schaffer ;
Date 1 Aug 2006
Journal Cell. 2005 Jul 29;122(2):169-82
Subject Molecular Networks; Cell Behavior
AbstractStochastic gene expression has been implicated in a variety of cellular processes, including cell differentiation and disease. In this issue of Cell, Weinberger et al. (2005) take an integrated computational-experimental approach to study the Tat transactivation feedback loop in HIV-1 and show that fluctuations in a key regulator, Tat, can result in a phenotypic bifurcation. This phenomenon is observed in an isogenic population where individual cells display two distinct expression states corresponding to latent and productive infection by HIV-1. These findings demonstrate the importance of stochastic gene expression in molecular "decision-making."
Source arXiv, q-bio/0608002
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