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Electrostatic theory of viral self-assembly: a toy model | | Tao Hu
; B. I. Shklovskii
; | | Date: |
4 Oct 2006 | | Subject: | Biomolecules | | Abstract: | Viruses self-assemble in host cells from identic capsid proteins and their genome consisting, for example, of a long single stranded (ss) RNA. For a big class of T = 3 viruses capsid proteins have long positive flexible N-tails. We explore the role played by the Coulomb interaction between the brush of positive N-tails rooted at the inner surface of the capsid and the negative ss RNA molecule. We show that viruses are most stable when the total length of ss RNA is close to the total length of the tails. For such a structure the absolute value of total (negative) charge of ss RNA is approximately two times larger than charge of the capsid. This conclusion agrees with available structural data. | | Source: | arXiv, q-bio/0610009 | | Services: | Forum | Review | PDF | Favorites | |
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