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Directionality is an inherent property of biochemical networks | | Feng Yang
; Feng Qi
; Daniel A. Beard
; | | Date: |
2 Jan 2007 | | Subject: | Molecular Networks | | Abstract: | The current procedure for determining feasible reaction directions for large-scale metabolic network is less concrete and arbitrary to some degree. This work demonstrates that the reaction directionality, which is constrained by mass balance and thermodynamic constraints, is an inherent property of a given network. It shows that the solution space constrained by physiochemical constraints can be approximated by a set of linearized subspaces in which mass- and thermodynamic balance are guaranteed. The presented method potentially can be used to {it ab initio} predict reaction directions of genome-scale networks based solely on the network stoichoimetric matrix. | | Source: | arXiv, q-bio/0701004 | | Services: | Forum | Review | PDF | Favorites | |
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