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Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
Takahiro Maeda ; Taha Merghoub ; Robin M Hobbs ; Lin Dong ; Manami Maeda ; Johannes Zakrzewski ; Marcel R M van den Brink ; Arthur Zelent ; Hirokazu Shigematsu ; Koichi Akashi ; Julie Teruya-Feldstein ; Giorgio Cattoretti ; Pier Paolo Pandolfi ;
Date:	11 May 2007
Journal:	Science, 316 (5826), 860-6
Abstract:	Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell’s determination of B versus T lineage.
Source:	PubMed, pmid17495164 doi: 10.1126/science.1140881
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