Science-advisor
REGISTER info/FAQ
Login
username
password
     
forgot password?
register here
 
Research articles
  search articles
  reviews guidelines
  reviews
  articles index
My Pages
my alerts
  my messages
  my reviews
  my favorites
 
 
Stat
Members: 3643
Articles: 2'488'730
Articles rated: 2609

29 March 2024
 
  » » arxiv » 249992

 Article forum


Model for processive movement of dynein
Ping Xie ; Shuo-Xing Dou ; Peng-Ye Wang ;
Date 11 Nov 2004
Subject Biomolecules | q-bio.BM
AbstractA model for the processive movement of dynein is presented based on experimental observations available. In the model, the change from strong microtubule-binding to weak binding of dynein is determined naturally by the variation of the relative orientation between the two interacting surfaces of the stalk tip and the microtubule as the stalk rotates from the ADP.Vi-state orientation to the apo-state orientation. This means that the puzzling communication from the ATP binding site in the globular head to the MT-binding site in the tip of the stalk, which is prerequisite in the conventional model, is not required. Using the present model, the previous experimental results, such as (i) the step size of a dynein being an integer times of the period of the MT lattice, (ii) the dependence of the step size on load, i.e., the step size decreasing with the increase of load, and (iii) the stall force being proportional to [ATP] at low [ATP] and becoming saturated at high [ATP], are well explained.
Source arXiv, q-bio.BM/0411023
Services Forum | Review | PDF | Favorites   
 

No message found in this article forum.  You have a question or message about this article? Ask the community and write a message in the forum.
If you want to rate this article, please use the review section..

Subject of your forum message:
Write your forum message below (min 50, max 2000 characters)

2000 characters left.
Please, read carefully your message since you cannot modify it after submitting.

  To add a message in the forum, you need to login or register first. (free): registration page






ScienXe.org
» my Online CV
» Free


News, job offers and information for researchers and scientists:
home  |  contact  |  terms of use  |  sitemap
Copyright © 2005-2024 - Scimetrica