forgot password?
register here
Research articles
  search articles
  reviews guidelines
  articles index
My Pages
my alerts
  my messages
  my reviews
  my favorites
Members: 3196
Articles: 2'203'744
Articles rated: 2592

28 May 2022
  » 917937

 Article forum

Model for unidirectional movement of axonemal and cytoplasmic dynein molecules
Ping Xie ; Shuo-Xing Dou ; Peng-Ye Wang ; PDF only ;
Date 8 Jun 2006
Subject Biomolecules
AbstractA model for the unidirectional movement of dynein is presented based on structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule is independent of its nucleotide state and the change between strong and weak microtubule-binding is determined naturally by the variation of relative orientation between the stalk and microtubule as the stalk rotates following nucleotide-state transition. Thus the enigmatic communication from the ATP binding site in the globular domain to the far MT-binding site in the tip of the stalk, which is prerequisite in conventional models, is not required. Using the present model, the previous experimental results such as the effect of ATP and ADP bindings on dissociation of dynein from microtubule, the processive movement of single-headed axonemal dyneins at saturating ATP concentration, the load dependence of step size for the processive movement of two-headed cytoplasmic dyneins and the dependence of stall force on ATP concentration can be well explained.
Source arXiv, q-bio/0606007
Services Forum | Review | PDF | Favorites   

No message found in this article forum.  You have a question or message about this article? Ask the community and write a message in the forum.
If you want to rate this article, please use the review section..

Subject of your forum message:
Write your forum message below (min 50, max 2000 characters)

2000 characters left.
Please, read carefully your message since you cannot modify it after submitting.

  To add a message in the forum, you need to login or register first. (free): registration page
» my Online CV
» Free

News, job offers and information for researchers and scientists:
home  |  contact  |  terms of use  |  sitemap
Copyright © 2005-2022 - Scimetrica