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Article overview
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Design and Characterisation of Tissue-Mimicking Gel Phantoms for Diffusion Kurtosis Imaging | | Ziyafer Gizem Portakal
; Sophie Shermer
; Emiliano Spezi
; Teresa Perrett
; Nina Tuncel
; Jonathan Phillips
; | | Date: |
1 Sep 2016 | | Abstract: | The purpose of the study was to create tissue-mimicking gel phantoms
appropriate for diffusion kurtosis imaging (DKI). Diffusion coefficients,
including the well-known apparent diffusion coefficient (ADC) and the diffusion
coefficient based on the kurtosis model, as well as (excess) kurtosis values
were experimentally determined for gels made of agar, agarose and polyvinyl
alcohol (PVA). Although we observe an increase in kurtosis with the
concentration of the gelling agents, the values obtained from
diffusion-weighted magnetic resonance imaging (DW-MRI) were too low to mimic
the range of values reported in the literature for various healthy and diseased
tissues. To create tissue-mimicking gels phantoms with more realistic kurtosis
values, different concentrations of glass microbeads were added. Experimental
characterisation showed that realistic kurtosis values for a range of tissues
may be obtained by varying the concentration of the gelling agents and glass
microbeads appropriately. To assess the effect of adding glass microbeads on
other key properties such as relaxation times, saturation recovery and multi
spin-echo relaxometry experiments were performed on all gel phantoms. The gel
phantoms were also examined using computed tomography (CT) to evaluate their
homogeneity and observe the effect of glass microbeads on the CT numbers of the
phantoms. | | Source: | arXiv, 1608.8542 | | Services: | Forum | Review | PDF | Favorites | |
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