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18 February 2025
 
  » arxiv » 1609.0312

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Quantum correlation enhanced super-resolution localization microscopy
Yonatan Israel ; Ron Tenne ; Dan Oron ; Yaron Silberberg ;
Date 1 Sep 2016
AbstractIn standard localization microscopy methods a small number of emitters are sparsely photoswitched, typically not more than one flourophore per diffraction limited spot, limiting the temporal resolution of super-resolved images. Localization of a non-sparse scene requires a precise estimate for the number of active emitters. Quantum correlations in the emitted fluorescence can probe the number of activated emitters, exploiting the fact that a single fluorophore emits a single photon at a time. To obtain this additional information, which is not provided by conventional cameras, we employ a new imaging configuration based on single-photon avalanche detectors (SPAD). Here we demonstrate a 20nm resolution localization and single-particle tracking (SPT) of non-sparsely activated emitters, which may facilitate super-resolved imaging at enhanced temporal resolution.
Source arXiv, 1609.0312
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