|
| | | | |
| | | |
| Stat |
Members: 3669
Articles: 2'599'751
Articles rated: 2609
24 March 2025 |
|
| | | | |
|
Article overview
| |
|
|
Choice of spatial discretisation influences the progression of viral infection within multicellular tissues | | Thomas Williams
; James McCaw
; James Osborne
; | | Date: |
1 Aug 2022 | | Abstract: | There has been an increasing recognition of the utility of models of the
spatial dynamics of viral spread within tissues. Multicellular models, where
cells are represented as discrete regions of space coupled to a virus density
surface, are a popular approach to capture these dynamics. Conventionally, such
models are simulated by discretising the viral surface and depending on the
rate of viral diffusion and other considerations, a finer or coarser
discretisation may be used. The impact that this choice may have on the
behaviour of the system has not been studied. Here we demonstrate that, if
rates of viral diffusion are small, then the choice of spatial discretisation
of the viral surface can have quantitative and even qualitative influence on
model outputs. We investigate in detail the mechanisms driving these phenomena
and discuss the constraints on the design and implementation of multicellular
viral dynamics models for different parameter configurations. | | Source: | arXiv, 2208.00684 | | Services: | Forum | Review | PDF | Favorites | |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
|
| |
|
|
|
REGISTER