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25 January 2025 |
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Article overview
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Refraction beats attenuation in breast CT | | Michał Rawlik
; Alexandre Pereira
; Simon Spindler
; Zhentian Wang
; Lucia Romano
; Konstantins Jefimovs
; Zhitian Shi
; Maxim Polikarpov
; Jinqiu Xu
; Marie-Christine Zdora
; Stefano van Gogh
; Martin Stauber
; Eduardo Yukihara
; Jeppe Brage Christensen
; Rahel Kubik-Huch
; Tilo Niemann
; Cornelia Leo
; Zsuzsanna Varga
; Andreas Boss
; Marco Stampanoni
; | | Date: |
1 Jan 2023 | | Abstract: | For a century, clinical X-ray imaging has visualised only the attenuation
properties of tissue, which fundamentally limits the contrast, particularly in
soft tissues like the breast. Imaging based on refraction can overcome this
limitation, but so far has been constrained to high-dose ex-vivo applications
or required highly coherent X-ray sources, like synchrotrons. It has been
predicted that grating interferometry (GI) could eventually allow computed
tomography (CT) to be more dose-efficient. However, the benefit of refraction
in clinical CT has not been demonstrated so far. Here we show that GI-CT is
more dose-efficient in imaging of breast tissue than conventional CT. Our
system, based on a 70kVp X-ray tube source and commercially available gratings,
demonstrated superior quality, in terms of adipose-to-glandular tissue
contrast-to-noise ratio (CNR), of refraction-contrast compared to the
attenuation images. The fusion of the two modes of contrast outperformed
conventional CT for spatial resolutions better than 263{mu}m and an average
dose to the breast of 16mGy, which is in the clinical breast CT range. Our
results show that grating interferometry can significantly reduce the dose,
while maintaining the image quality, in diagnostic breast CT. Unlike
conventional absorption-based CT, the sensitivity of refraction-based imaging
is far from being fully exploited, and further progress will lead to
significant improvements of clinical X-ray CT. | | Source: | arXiv, 2301.00455 | | Services: | Forum | Review | PDF | Favorites | |
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