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24 June 2024
 
  » arxiv » 2302.00142

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Emerging Trends in Droplet Microfluidic Screens for Biotechnology
Carlos Vidal-Céspedes ; Tobias Wenzel ;
Date 1 Feb 2023
AbstractDroplet microfluidic screens are an important high-throughput technology in the discovery, product optimization, and analysis of biotechnology applications. This review discusses the current use of droplet-based screens, explains the emerging trend of interaction assays in microfluidic droplets, and explains why droplets are particularly suited for this application. The interactions of many different biological entities can be screened, including antibodies, enzymes, DNA, RNA, eukaryotic cells and microorganisms, drugs, and other molecules. Recent breakthroughs have enabled new scales of bioanalysis and biotechnological product design. Recent methodology advances that expand droplet-based screens to new environments are also highlighted, including cargo delivery inside the body, application of synthetic gene circuits in the natural environment, 3D-printing, and designing droplet structures that respond to environmental signals.
Source arXiv, 2302.00142
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