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23 April 2024 |
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5-Methyltetrahydrofolic Acid as a Mediator in the Formation of Pyridoindoles | | Lewis R Mandel
; Avery Rosegay
; Robert W Walker
; W J A Vandenheuvel
; Joshua Rokach
; | | Date: |
22 Nov 1974 | | Journal: | Science, 186 (4165), 741-743 | | Abstract: | Enzymes from chick and rat tissues catalyze the reaction of N-methyl tryptamine with 5-methyltetrahydrofolic acid to form 2,3,4,9-tetrahydro-2-methyl-1H-pyrido[3,4b] indole. N,N-Dimethyltryptamine was not formed. With tryptamine as substrate the product is 2,3,4,9-tetrahydro-1H-pyrido[3,4b] indole and not N-methyltryptamine. These pyridoindoles were not formed when S-adenosylmethionine was cosubstrare. | | Source: | PubMed, pmid17792267 doi: 10.1126/science.186.4165.741 | | Services: | Forum | Review | Favorites | |
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