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13 February 2025
 
  » pubmed » pmid2580351

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Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes
B J Song ; H V Gelboin ; S S Park ; G C Tsokos ; F K Friedman ;
Date 26 Apr 1985
Journal Science, 228 (4698), 490-2
AbstractA multiplicity of cytochromes P-450 is responsible for the detoxification and activation of xenobiotics such as drugs and carcinogens. Individual differences in sensitivity to these agents may reside in the cytochrome P-450 phenotype. A monoclonal antibody-directed radioimmunoassay was developed that detects epitope-specific cytochromes P-450 in human placentas and peripheral lymphocytes. Placentas from women who smoked cigarettes contained greater amounts of cytochrome P-450 with the monoclonal antibody-specific epitope than placentas from nonsmokers. The amount of this cytochrome P-450 in human peripheral lymphocytes increased after treatment of the mitogenized lymphocytes with the cytochrome P-450 inducer benz[a]anthracene.
Source PubMed, pmid2580351
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