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Article overview
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Monoclonal antibody-directed radioimmunoassay detects cytochrome P-450 in human placenta and lymphocytes | B J Song
; H V Gelboin
; S S Park
; G C Tsokos
; F K Friedman
; | Date: |
26 Apr 1985 | Journal: | Science, 228 (4698), 490-2 | Abstract: | A multiplicity of cytochromes P-450 is responsible for the detoxification and activation of xenobiotics such as drugs and carcinogens. Individual differences in sensitivity to these agents may reside in the cytochrome P-450 phenotype. A monoclonal antibody-directed radioimmunoassay was developed that detects epitope-specific cytochromes P-450 in human placentas and peripheral lymphocytes. Placentas from women who smoked cigarettes contained greater amounts of cytochrome P-450 with the monoclonal antibody-specific epitope than placentas from nonsmokers. The amount of this cytochrome P-450 in human peripheral lymphocytes increased after treatment of the mitogenized lymphocytes with the cytochrome P-450 inducer benz[a]anthracene. | Source: | PubMed, pmid2580351 | Services: | Forum | Review | Favorites |
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