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Article overview
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Evidence for a malarial parasite interaction site on the major transmembrane protein of the human erythrocyte | M J Friedman
; M Fukuda
; R A Laine
; | Date: |
5 Apr 1985 | Journal: | Science, 228 (4695), 75-7 | Abstract: | Soluble oligosaccharides derived from the surface of human erythrocytes were tested for their ability to competitively inhibit invasion of erythrocytes by Plasmodium falciparum, a malarial parasite. Invasion was most effectively inhibited by erythroglycan, a carbohydrate component of the band 3 transmembrane protein. The lactosamine chains of erythroglycan contributed much of the inhibitory activity. This indication of a primary parasite interaction site on band 3 supports a role for this protein in mediating the radical alterations of the erythrocyte cytoskeleton that accompany invasion. | Source: | PubMed, pmid3883494 | Services: | Forum | Review | Favorites |
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