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Article overview
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Cyclosporin A binding to calmodulin: a possible site of action on T lymphocytes | P M Colombani
; A Robb
; A D Hess
; | Date: |
19 Apr 1985 | Journal: | Science, 228 (4697), 337-9 | Abstract: | Cyclosporin A, a potent immunosuppressive agent, has been widely used to treat patients with solid organ transplants. Although its precise mechanism of action is unknown, it appears to inhibit subsets of T lymphocytes at an early stage in cell activation. Fluorescent, fully active derivatives of cyclosporin A and calmodulin, a protein that binds calcium and is therefore essential to normal cell function, were utilized to demonstrate that cyclosporin A binds to calmodulin. Flow cytometry showed that the calmodulin inhibitors R24571 and W-7 competitively inhibited binding of cyclosporin A to cloned T lymphocytes. Cyclosporin A inhibited the calmodulin-dependent activation of phosphodiesterase in a dose-dependent manner. Binding of cyclosporin A to calmodulin may prevent the latter’s role in the activation of the second messengers and enzymes required for effective cell proliferation and function in the immune response. | Source: | PubMed, pmid3885394 | Services: | Forum | Review | Favorites |
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