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12 February 2025 |
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Article overview
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Genotoxicity of formaldehyde in cultured human bronchial fibroblasts | R C Grafstrom
; R D Curren
; L L Yang
; C C Harris
; | Date: |
5 Apr 1985 | Journal: | Science, 228 (4695), 89-91 | Abstract: | Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens. | Source: | PubMed, pmid3975633 | Services: | Forum | Review | Favorites |
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