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28 March 2024
 
  » pubmed » pmid4137861

 Article overview


Neonatal tolerance induced by antibody against antigen-specific receptor
D S Strayer ; H Cosenza ; W M Lee ; D A Rowley ; H Köhler ;
Date 15 Nov 1974
Journal Science, 186 (4164), 640-3
AbstractSpecific immunologic unresponsiveness is induced by injecting adult or neonatal mice with antibody against antigen-specific receptor (antireceptor antibody). Suppression in mice treated as adults lasts several weeks, and cells from these suppressed mice respond normally in culture. In contrast, unresponsiveness induced in neonatal mice is long-lasting; cells from these mice do not respond in culture and do not affect the response of normal cells. Evidently, antireceptor antibody reversibly blocks antigen receptors in adult animals, but induces unresponsiveness in neonatal mice by depleting the clone of receptor-bearing cells.
Source PubMed, pmid4137861
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