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Pancreatic ribonuclease: enzymic and physiological properties of a cross-linked dimer | | J Bartholeyns
; S Moore
; | | Date: |
1 Nov 1974 | | Journal: | Science, 186 (4162), 444-5 | | Abstract: | Monomeric ribonuclease A has very low activity toward typically double-stranded RNA’s; the dimeric form of ribonuclease A obtained by cross linking the enzyme by dimethyl suberimidate has more than 78 times the activity of the monomer toward polyadenylate . polyuridylate and 440 times the activity of the monomer toward the double-stranded RNA of a virus from Penicillium chrysogenum. The half-life of the dimer in the bloodstream of the rat is 12 times that of the mononmer. | | Source: | PubMed, pmid4213284 | | Services: | Forum | Review | Favorites | |
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