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29 March 2024
 
  » pubmed » pmid4272136

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Apomorphine: modification of its hyperthermic effect in rabbits by p-chlorophenylalanine
R M Quock ; A Horita ;
Date 8 Feb 1974
Journal Science, 183 (124), 539-40
AbstractThe hyperthermic response of rabbits to apomorphine, a dopaminergic agonist, is abolished by prior treatment with p-chlorophenylalanine. If such 5-hydroxytryptamine (5-HT)-depleted animals are administered a peripherally acting decarboxylase inhibitor plus 5-hydroxytryptophan, central stores of 5-HT are regenerated and the hyperthermic response to apomorphine is restored in part. The effects of apomorphine in rabbits with elevated concentrations of 5-HT are not different from those in control animals. The behavioral effects of apomnorphine appear to be constant in all groups of animals tested. It is suggested that the hyperthermic effects of apomorphine in rabbits require the presence of 5-HT.
Source PubMed, pmid4272136
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