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29 March 2024
 
  » pubmed » pmid4358576

 Article overview


Paradoxical increase in rate of catabolism of low-density lipoproteins after hepatectomy
A D Sniderman ; T E Carew ; J G Chandler ; D Steinberg ;
Date 8 Feb 1974
Journal Science, 183 (124), 526-8
AbstractIt has been suggested that the liver may be a major site for irreversible degradation of low-density lipoprotein (LDL). The disappearance of autologous (125)I-labeled LDL from plasma was compared in intact and in hepatectomized swine. Contrary to expectations, the rate of irreversible removal of LDL from plasma was increased rather then decreased by hepatectomy. These studies suggest that the liver is not a major site for LDL removal. We propose further that the liver (or some function requiring an intact liver) may affect the metabolism of LDL in a manner that prolongs its lifetime in the plasma compartment.
Source PubMed, pmid4358576
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