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28 March 2024
 
  » pubmed » pmid4363578

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Angiotensin II- and angiotensin 3-induced aldosterone release vivo in the rat
W B Campbell ; S N Brooks ; W A Pettinger ;
Date 31 May 1974
Journal Science, 184 (140), 994-6
AbstractThe potential role of angiotensin II and its heptapeptide metabolite, des-aspartyl-angiotensin II, was studied in the conscious unanesthetized rat. Aldosterone release was induced by both peptides at physiologic doses (0.72 nanogram per minute). [I-Sarcosyl-8-alanyl]-angiotensin II (P-113 inhibited angiotensin II more effectively than des-aspartyl-angiotensin II (101 percent as compared to 82 percent). These results indicate that angiotensin controls aldosterone release in the rat and that des-aspartyl-angiotensin II (that is, angiotensin III) may be important in this sequence.
Source PubMed, pmid4363578
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