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28 March 2024 |
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Article overview
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Angiotensin II- and angiotensin 3-induced aldosterone release vivo in the rat | W B Campbell
; S N Brooks
; W A Pettinger
; | Date: |
31 May 1974 | Journal: | Science, 184 (140), 994-6 | Abstract: | The potential role of angiotensin II and its heptapeptide metabolite, des-aspartyl-angiotensin II, was studied in the conscious unanesthetized rat. Aldosterone release was induced by both peptides at physiologic doses (0.72 nanogram per minute). [I-Sarcosyl-8-alanyl]-angiotensin II (P-113 inhibited angiotensin II more effectively than des-aspartyl-angiotensin II (101 percent as compared to 82 percent). These results indicate that angiotensin controls aldosterone release in the rat and that des-aspartyl-angiotensin II (that is, angiotensin III) may be important in this sequence. | Source: | PubMed, pmid4363578 | Services: | Forum | Review | Favorites |
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