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19 April 2024

» pubmed » pmid4370218

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Neuroblastoma: drug-induced differentiation increases proportion of cytoplasmic RNA that contains polyadenylic acid
S C Bondy ; K N Prasad ; J L Purdy ;
Date:	25 Oct 1974
Journal:	Science, 186 (4161), 359-61
Abstract:	The production of cytoplasmic RNA that contains polyadenylic acid is increased, relative to total cytoplasmic RNA, in a neuroblastoma clone, NBE-(A), after induction of differentiation by 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone, an inhibitor of adenosine 3’,5’-monophosphate phosphodiesterase. The amount of RNA that contains polyadenylic acid in cytoplasm may be greater in such differentiated neuroblastoma cells than in proliferating control cells.
Source:	PubMed, pmid4370218
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