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29 March 2024
 
  » pubmed » pmid4413726

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Hycanthone analogs: dissociation of mutagenic effects from antischistosomal effects
P B Hulbert ; E Bueding ; P E Hartman ;
Date 15 Nov 1974
Journal Science, 186 (4164), 647-8
AbstractN-Oxidation at the diethylamino group of hycanthone, of lucanthone, and of two chlorobenzothiopyranoindazoles resulted in a marked reduction in mutagenic activity, while antischistosomal activity was retained or even enhanced. Introduction of chlorine into the 8-position of benzothiopyranoindazoles reduced acute toxicity but had no effect on chemnotherapeutic potency. These dissociations of biological activities indicate that safer antischistosomal compounds of this class can be developed.
Source PubMed, pmid4413726
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