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25 April 2024

» pubmed » pmid4432069

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Microtubule-macrotubule transitions: intermediates after exposure to the mitotic inhibitor vinblastine
R K Warfield ; G B Bouck ;
Date:	27 Dec 1974
Journal:	Science, 186 (4170), 1219-21
Abstract:	Vinblastine treatment of microtubule protein or intact microtubules assembled in vitro produced bifilar rings and bifilar helices. Suspentsions of rings and helices were demonstrated to bind [(3)H]colchicine, a diagnostic property of microtubule protein. Macrotubules are suggested to consist of tightly coiled helices formed by longitudinal compacting of loosely coiled protofilament pair intermediates.
Source:	PubMed, pmid4432069
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