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Hemoglobin switching in sheep and goats: occurrence of hemoglobins A and C in the same red cell | A W Nienhuis
; H F Bunn
; | Date: |
13 Sep 1974 | Journal: | Science, 185 (4155), 946-8 | Abstract: | Sheep and goats switch from the synthesis of hemoglobin A (alpha(2)beta(2)(A)) to hemoglobin C (alpha(2)beta(2)(C)) when made anemic. We have demonstrated the existence of the asymmetrical hybrid hemoglobin, alpha(2)beta(A)beta(C), in the circulating red cells of anemic sheep. These erythroid cells, therefore, synthesized both A and C hemoglobin simultaneously. Thus, the switch appears to be mediated by selective gene expression rather than by a clonal or cellular selective mechanism. | Source: | PubMed, pmid4469671 | Services: | Forum | Review | Favorites |
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