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Decrease in free cystine content of cultured cystinotic fibroblasts by ascorbic acid | | W A Kroll
; J A Schneider
; | | Date: |
13 Dec 1974 | | Journal: | Science, 186 (4168), 1040-2 | | Abstract: | The 100-fold increase in free cystine content characteristic of cultured skin fibroblasts from patients with nephropathic cystinosis was decreased more than 50 percent by addition of L-ascorbic acid to the culture medium at concentrations of 0.29 to 2.9 millimolar. Fresh ascorbic acid must be added to the culture medium daily to produce a progressive decrease of the free cystine content of the cells over a 3-day period. Upon removal of ascorbic acid from the medium, the free cystine content returns to its initial value. | | Source: | PubMed, pmid4469696 | | Services: | Forum | Review | Favorites | |
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