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Reversal by L-dopa of impaired learning due to destruction of the dopaminergic nigro-neostriatal projection | | A P Zis
; H C Fibiger
; A G Phillips
; | | Date: |
13 Sep 1974 | | Journal: | Science, 185 (4155), 960-2 | | Abstract: | Rats receiving bilateral stereotaxic injections of 6-hydroxydopamine into the zona compacta of the substantia nigra failed to learn a one-way active avoidance response. Small doses of L-dopa (1.5 milligrams per kilogram of body weight) in combination with a peripheral decarboxylase inhibitor reversed this impairment. Animals with lesions which acquired the avoidance response during L-dopa administration retained this response when drug treatment was discontinued. These experiments suggest that the dopaminergic nigro-neostriatal projection serves a critical function in the acquisition of learned instrumental responses. | | Source: | PubMed, pmid4471715 | | Services: | Forum | Review | Favorites | |
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