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19 April 2024

» pubmed » pmid4587442

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Aging increases susceptibility of mouse skin to DMBA carcinogenesis independent of general immune status
P Ebbesen ;
Date:	18 Jan 1974
Journal:	Science, 183 (121), 217-8
Abstract:	The dependence of chemical carcinogenesis on age of target tissue was studied by repeated DMBA-treatment of mouse skin grafted from old and young syngeneic donors to young recipients. Carcinomas developed on 39 percent (1.6/41) of grafts from old donors and on 12 percent (5/41) of grafts from young donors. The incidence of nonskin lymphoid tumors was highest in male recipients bearing grafts from old donors.
Source:	PubMed, pmid4587442
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