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29 March 2024
 
  » pubmed » pmid4594711

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Somatostatin: hypothalamic inhibitor of the endocrine pancreas
D J Koerker ; W Ruch ; E Chideckel ; J Palmer ; C J Goodner ; J Ensinck ; C C Gale ;
Date 26 Apr 1974
Journal Science, 184 (135), 482-4
AbstractSomatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.
Source PubMed, pmid4594711
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