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Carcinogenicity of methylchrysenes | D Hoffmann
; W E Bondinell
; E L Wynder
; | Date: |
18 Jan 1974 | Journal: | Science, 183 (121), 215-6 | Abstract: | Methylchrysenes are present in tobacco smoke and are suspected to contribute to the tumorigenicity of this inhalant. Chrysene and the six isomeric methylchrysenes were obtained in high purity (99.9 percent); they were tested on mouse skin for tumor initiating activity and carcinogenicity. The 3- and 6-methylchrysenes are strong tumor initiators, whereas the other five chrysenes have moderate initiatinig activity. 5-Methylchrysene is a strong carcinogen; the other chrysenes are inactive or weak carcinogens. | Source: | PubMed, pmid4808861 | Services: | Forum | Review | Favorites |
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