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Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen | | I D Bernstein
; M R Tam
; R C Nowinski
; | | Date: |
4 Jan 1980 | | Journal: | Science, 207 (4426), 68-71 | | Abstract: | Monoclonal antibodies against a thymus cell differentiation antigen (Thy-1.1) were effective in the therapy of a transplanted mouse leukemia. Passive immunization resulted in high titers of cytotoxic antibody in the serum of treated mice and the suppression of metastatic tumor cells. The tumor-suppressive effects of the monoclonal antibodies were amplified by the administration of exogenous complement. This combined antibody and complement therapy resulted in the cure of leukemia in a significant proportion of the treated animals. | | Source: | PubMed, pmid6965328 | | Services: | Forum | Review | Favorites | |
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