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Localisation of substance P immunoreactivity in amacrine cells of the retina | | H J Karten
; N Brecha
; | | Date: |
3 Jan 1980 | | Journal: | Nature, 283 (5742), 87-8 | | Abstract: | Since its actions on smooth muscle were first described by von Euler and Gaddum, substance P has been isolated and characterised as an undecapeptide. The distribution of substance P-like immunoreactivity in both the central and peripheral nervous systems and its reported excitatory action on neurones implicate substance P as a possible neurotransmitter and/or neuromodulator. Previous studies using bioassay and radioimmunoassay techniques have reported substance P in retinal extracts. Here we describe the specific immunohistochemical localisation of substance P-like immunoreactivity in a population of morphologically distinct amacrine cells of the pigeon retina. The localisation of substance P-like immunoreactivity and the recent localisation of enkephalin-like and somatostatin-like immunoreactivity in other types of amacrine cells suggest that the neuropeptides have a specific role in retinal function. | | Source: | PubMed, pmid6985713 | | Services: | Forum | Review | Favorites | |
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