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The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing | | W Jiang
; W J Swiggard
; C Heufler
; M Peng
; A Mirza
; R M Steinman
; M C Nussenzweig
; | | Date: |
11 May 1995 | | Journal: | Nature, 375 (6527), 151-5 | | Abstract: | Dendritic cells and thymic epithelial cells perform important immunoregulatory functions by presenting antigens in the form of peptides bound to cell-surface major histocompatibility complex (MHC) molecules to T cells. Whereas B cells are known to present specific antigens efficiently through their surface immunoglobins, a comparable mechanism for the capture and efficient presentation of diverse antigens by dendritic cells and thymic epithelial cells has not previously been described. We show here that their antigen-presentation function is associated with the high-level expression of DEC-205, an integral membrane protein homologous to the macrophage mannose receptor and related receptors which are able to bind carbohydrates and mediate endocytosis. DEC-205 is rapidly taken up by means of coated pits and vesicles, and is delivered to a multivesicular endosomal compartment that resembles the MHC class II-containing vesicles implicated in antigen presentation. Rabbit antibodies that bind DEC-205 are presented to reactive T-cell hybridomas 100-fold more efficiently than rabbit antibodies that do not bind DEC-205. Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. | | Source: | PubMed, pmid7753172 doi: 10.1038/375151a0 | | Services: | Forum | Review | Favorites | |
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