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Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+] | | Y O Chernoff
; S L Lindquist
; B Ono
; S G Inge-Vechtomov
; S W Liebman
; | | Date: |
12 May 1995 | | Journal: | Science, 268 (5212), 880-4 | | Abstract: | The yeast non-Mendelian factor [psi+] has been suggested to be a self-modified protein analogous to mammalian prions. Here it is reported that an intermediate amount of the chaperone protein Hsp104 was required for the propagation of the [psi+] factor. Over-production or inactivation of Hsp104 caused the loss of [psi+]. These results suggest that chaperone proteins play a role in prion-like phenomena, and that a certain level of chaperone expression can cure cells of prions without affecting viability. This may lead to antiprion treatments that involve the alteration of chaperone amounts or activity. | | Source: | PubMed, pmid7754373 | | Services: | Forum | Review | Favorites | |
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