|
| | | | |
| | | |
| Stat |
Members: 3645
Articles: 2'504'928
Articles rated: 2609
26 April 2024 |
|
| | | | |
|
Article overview
| |
|
|
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells | | David P Corey
; Jaime García-Añoveros
; Jeffrey R Holt
; Kelvin Y Kwan
; Shuh-Yow Lin
; Melissa A Vollrath
; Andrea Amalfitano
; Eunice L-M Cheung
; Bruce H Derfler
; Anne Duggan
; Gwénaëlle S G Géléoc
; Paul A Gray
; Matthew P Hoffman
; Heidi L Rehm
; Daniel Tamasauskas
; Duan-Sun Zhang
; | | Date: |
9 Dec 2004 | | Journal: | Nature, 432 (7018), 723-30 | | Abstract: | Mechanical deflection of the sensory hair bundles of receptor cells in the inner ear causes ion channels located at the tips of the bundle to open, thereby initiating the perception of sound. Although some protein constituents of the transduction apparatus are known, the mechanically gated transduction channels have not been identified in higher vertebrates. Here, we investigate TRP (transient receptor potential) ion channels as candidates and find one, TRPA1 (also known as ANKTM1), that meets criteria for the transduction channel. The appearance of TRPA1 messenger RNA expression in hair cell epithelia coincides developmentally with the onset of mechanosensitivity. Antibodies to TRPA1 label hair bundles, especially at their tips, and tip labelling disappears when the transduction apparatus is chemically disrupted. Inhibition of TRPA1 protein expression in zebrafish and mouse inner ears inhibits receptor cell function, as assessed with electrical recording and with accumulation of a channel-permeant fluorescent dye. TRPA1 is probably a component of the transduction channel itself. | | Source: | PubMed, pmid15483558 doi: 10.1038/nature03066 | | Services: | Forum | Review | Favorites | |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
|
| |
|
|
|
|
News, job offers and information for researchers and scientists:
| |
REGISTER