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26 April 2024 |
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Unique structure of murine interleukin-2 as deduced from cloned cDNAs | | N Kashima
; C Nishi-Takaoka
; T Fujita
; S Taki
; G Yamada
; J Hamuro
; T Taniguchi
; | | Date: |
6 Jan 1985 | | Journal: | Nature, 313 (6001), 402-4 | | Abstract: | Interleukin-2 (IL-2) is a lymphokine originally described as a humoral factor required for the continued proliferation of activated T-cell clones. It also seems to be involved in the mitogenic response of thymocytes, in augmenting natural killer cell activity, in the generation of cytotoxic T cells and in the induction of other lymphokines such as gamma-interferon and a B-cell growth factor (BCGF-1). More recently, there has been evidence for the involvement of IL-2 per se in the stimulation of B-cell growth (ref. 10 and T. Kishimoto and J. Vilcek, personal communications). We have reported previously the cloning and expression of a human IL-2 complementary DNA. The cDNA encodes biologically active IL-2 which would consist of 153 amino acids, including a signal sequence. Because so much of the work on IL-2 has been done in the human and mouse, we sought to obtain cDNA encoding murine IL-2, and we now report the cloning, expression and sequence analysis of murine IL-2 cDNAs. The longest cDNA insert encodes a polypeptide of 169 amino acids, containing unique repeats of a CAG sequence which would encode 12 consecutive glutamine residues within the active IL-2 molecule. | | Source: | PubMed, pmid2578624 | | Services: | Forum | Review | Favorites | |
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