|
| | | | |
| | | |
| Stat |
Members: 3645
Articles: 2'506'133
Articles rated: 2609
26 April 2024 |
|
| | | | |
|
Article overview
| |
|
|
A common fold mediates vertebrate defense and bacterial attack | | Carlos J Rosado
; Ashley M Buckle
; Ruby H P Law
; Rebecca E Butcher
; Wan-Ting Kan
; Catherina H Bird
; Kheng Ung
; Kylie A Browne
; Katherine Baran
; Tanya A Bashtannyk-Puhalovich
; Noel G Faux
; Wilson Wong
; Corrine J Porter
; Robert N Pike
; Andrew M Ellisdon
; Mary C Pearce
; Stephen P Bottomley
; Jonas Emsley
; A Ian Smith
; Jamie Rossjohn
; Elizabeth L Hartl
; Ilia Voskoboinik
; Joseph A Trapani
; Phillip I Bird
; Michelle A Dunstone
; James C Whisstock
; | | Date: |
14 Sep 2007 | | Journal: | Science, 317 (5844), 1548-51 | | Abstract: | Proteins containing membrane attack complex/perforin (MACPF) domains play important roles in vertebrate immunity, embryonic development, and neural-cell migration. In vertebrates, the ninth component of complement and perforin form oligomeric pores that lyse bacteria and kill virus-infected cells, respectively. However, the mechanism of MACPF function is unknown. We determined the crystal structure of a bacterial MACPF protein, Plu-MACPF from Photorhabdus luminescens, to 2.0 angstrom resolution. The MACPF domain reveals structural similarity with poreforming cholesterol-dependent cytolysins (CDCs) from Gram-positive bacteria. This suggests that lytic MACPF proteins may use a CDC-like mechanism to form pores and disrupt cell membranes. Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection. | | Source: | PubMed, pmid17717151 doi: 10.1126/science.1144706 | | Services: | Forum | Review | Favorites | |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
|
| |
|
|
|
|
News, job offers and information for researchers and scientists:
| |
REGISTER