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26 April 2024

» pubmed » pmid17068255

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BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling
Henrike Berkefeld ; Claudia A Sailer ; Wolfgang Bildl ; Volker Rohde ; Jörg-Oliver Thumfart ; Silke Eble ; Norbert Klugbauer ; Ellen Reisinger ; Josef Bischofberger ; Dominik Oliver ; Hans-Günther Knaus ; Uwe Schulte ; Bernd Fakler ;
Date:	27 Oct 2006
Journal:	Science, 314 (5799), 615-20
Abstract:	Large-conductance calcium- and voltage-activated potassium channels (BKCa) are dually activated by membrane depolarization and elevation of cytosolic calcium ions (Ca2+). Under normal cellular conditions, BKCa channel activation requires Ca2+ concentrations that typically occur in close proximity to Ca2+ sources. We show that BKCa channels affinity-purified from rat brain are assembled into macromolecular complexes with the voltage-gated calcium channels Cav1.2 (L-type), Cav2.1 (P/Q-type), and Cav2.2 (N-type). Heterologously expressed BKCa-Cav complexes reconstitute a functional "Ca2+ nanodomain" where Ca2+ influx through the Cav channel activates BKCa in the physiological voltage range with submillisecond kinetics. Complex formation with distinct Cav channels enables BKCa-mediated membrane hyperpolarization that controls neuronal firing pattern and release of hormones and transmitters in the central nervous system.
Source:	PubMed, pmid17068255 doi: 10.1126/science.1132915
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