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26 April 2024

» pubmed » pmid14704431

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A map of the interactome network of the metazoan C. elegans
Siming Li ; Christopher M Armstrong ; Nicolas Bertin ; Hui Ge ; Stuart Milstein ; Mike Boxem ; Pierre-Olivier Vidalain ; Jing-Dong J Han ; Alban Chesneau ; Tong Hao ; Debra S Goldberg ; Ning Li ; Monica Martinez ; Jean-François Rual ; Philippe Lamesch ; Lai Xu ; Muneesh Tewari ; Sharyl L Wong ; Lan V Zhang ; Gabriel F Berriz ; Laurent Jacotot ; Philippe Vaglio ; Jérôme Reboul ; Tomoko Hirozane-Kishikawa ; Qianru Li ; Harrison W Gabel ; Ahmed Elewa ; Bridget Baumgartner ; Debra J Rose ; Haiyuan Yu ; Stephanie Bosak ; Reynaldo Sequerra ; Andrew Fraser ; Susan E Mango ; William M Saxton ; Susan Strome ; Sander Van Den Heuvel ; Fabio Piano ; Jean Vandenhaute ; Claude Sardet ; Mark Gerstein ; Lynn Doucette-Stamm ; Kristin C Gunsalus ; J Wade Harper ; Michael E Cusick ; Frederick P Roth ; David E Hill ; Marc Vidal ;
Date:	23 Jan 2004
Journal:	Science, 303 (5657), 540-3
Abstract:	To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico, the current version of the Worm Interactome (WI5) map contains approximately 5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.
Source:	PubMed, pmid14704431 doi: 10.1126/science.1091403
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