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Control of effector CD8+ T cell function by the transcription factor Eomesodermin | | Erika L Pearce
; Alan C Mullen
; Gislâine A Martins
; Connie M Krawczyk
; Anne S Hutchins
; Valerie P Zediak
; Monica Banica
; Catherine B DiCioccio
; Darrick A Gross
; Chai-An Mao
; Hao Shen
; Nezih Cereb
; Soo Y Yang
; Tullia Lindsten
; Janet Rossant
; Christopher A Hunter
; Steven L Reiner
; | | Date: |
7 Nov 2003 | | Journal: | Science, 302 (5647), 1041-3 | | Abstract: | Activated CD8+ T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8+ T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8+ T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8+ T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity. | | Source: | PubMed, pmid14605368 doi: 10.1126/science.1090148 | | Services: | Forum | Review | Favorites | |
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