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26 April 2024

» pubmed » pmid12775843

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Characterization of mammalian selenoproteomes
Gregory V Kryukov ; Sergi Castellano ; Sergey V Novoselov ; Alexey V Lobanov ; Omid Zehtab ; Roderic Guigó ; Vadim N Gladyshev ;
Date:	30 May 2003
Journal:	Science, 300 (5624), 1439-43
Abstract:	In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.
Source:	PubMed, pmid12775843 doi: 10.1126/science.1083516
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