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26 April 2024 |
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Priming of memory but not effector CD8 T cells by a killed bacterial vaccine | | G Lauvau
; S Vijh
; P Kong
; T Horng
; K Kerksiek
; N Serbina
; R A Tuma
; E G Pamer
; | | Date: |
23 Nov 2001 | | Journal: | Science, 294 (5547), 1735-9 | | Abstract: | Killed or inactivated vaccines targeting intracellular bacterial and protozoal pathogens are notoriously ineffective at generating protective immunity. For example, vaccination with heat-killed Listeria monocytogenes (HKLM) is not protective, although infection with live L. monocytogenes induces long-lived, CD8 T cell-mediated immunity. We demonstrate that HKLM immunization primes memory CD8 T lymphocyte populations that, although substantial in size, are ineffective at providing protection from subsequent L. monocytogenes infection. In contrast to live infection, which elicits large numbers of effector CD8 T cells, HKLM immunization primes T lymphocytes that do not acquire effector functions. Our studies show that it is possible to dissociate T cell-dependent protective immunity from memory T cell expansion, and that generation of effector T cells may be necessary for long-term protective immunity. | | Source: | PubMed, pmid11721060 doi: 10.1126/science.1064571 | | Services: | Forum | Review | Favorites | |
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