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26 April 2024

» pubmed » pmid11141566

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Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors
S T Davis ; B G Benson ; H N Bramson ; D E Chapman ; S H Dickerson ; K M Dold ; D J Eberwein ; M Edelstein ; S V Frye ; R T Gampe Jr ; R J Griffin ; P A Harris ; A M Hassell ; W D Holmes ; R N Hunter ; V B Knick ; K Lackey ; B Lovejoy ; M J Luzzio ; D Murray ; P Parker ; W J Rocque ; L Shewchuk ; J M Veal ; D H Walker ; L F Kuyper ;
Date:	5 Jan 2001
Journal:	Science, 291 (5501), 134-7
Abstract:	Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.
Source:	PubMed, pmid11141566 doi: 10.1126/science.291.5501.134
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